Relation between Neurotransmitters and NK Cells in Adrenal and Breast Cancer

Purpose: Data on microarray gene expression The Gene Expression Omnibus (GEO) provided information expression. Transcription GEO two profiles of human NK cells from breast and adrenal tumors (GSE179509 GSE143383). processing normalization Dseq2 tool in the R programming language was used to standardize raw data GEO. following analyses were carried out: fold change P-value analysis, volcano plot, network GEPIA, David pathway analysis. In this paper, using Venny software, we discovered 2 genes that are shared by neurotransmitters cancer cancer. Between these pathways, they a part of, network. Pathway analysis revealed mostly linked neurotransmitter apoptotic pathways. tumors, HRH1 GABRD be connected cells. response almost all effective. It is thus postulated diagnosis may affected up-or down-regulation genes. Methods: Microarray obtained profile cancers Processing normalized with package software. Fold P value Volcano performed. Results: article, found common program, resulting We identified between pathways belong to. showed associated apoptosis pathway. Conclusion: cancers. Almost effective Therefore, it hypothesized downregulation or upregulation affect diagnosis.